Oxymetholone

What Is Zyvex Phara Oxymetholone?

Oxymetholone, most commonly known by the brand name Anadrol-50, is the most potent oral anabolic steroid ever developed for human use. First synthesized in the 1960s by Syntex Pharmaceuticals, it was originally developed for a highly specific medical purpose: the treatment of anemias caused by deficient red blood cell production. Today, its FDA-approved label still reflects this hematological indication, covering conditions such as acquired aplastic anemia, congenital aplastic anemia, myelofibrosis, and hypoplastic anemias resulting from myelotoxic drugs.

Chemically, oxymetholone is a DHT derivative with a 17-alpha alkylated structure the modification that allows oral bioavailability at the cost of significant hepatic strain. Its full chemical name is 17β-hydroxy-2-(hydroxymethylene)-17-methyl-5α-androstan-3-one. Each tablet contains 50 mg of the active steroid, delivered in a scored oral tablet for flexible dosing.

Oxymetholone Cycle Guide

Zyvex Pharma Oxymetholone has a half-life of approximately 8 to 9 hours, with peak concentrations reached around 1.5 hours post-dose and active effects lasting approximately 12 hours. This relatively short half-life allows for once or twice-daily dosing.

Standard Dosage:

• Beginner/Mild:25 mg daily
• Standard Bodybuilding Dose:50 mg daily
• Advanced:100 mg daily
• Maximum Recommended:100 mg daily higher doses dramatically increase side effects with diminishing returns

Cycle Duration:

• Recommended:4 to 6 weeks maximum
• Critical Warning:Extended use beyond 6 weeks significantly increases the risk of severe hepatic complications, including liver tumors and peliosis hepatitis (blood-filled cysts in the liver)

Administration Protocol:

• For once-daily dosing, take in the morning with food to minimize gastrointestinal discomfort
• For split dosing (preferred at 100 mg), divide into two 50 mg doses (morning and evening)
• Oxymetholone has approximately 80% bioavailability

The "Kickstart" Application:
Oxymetholone earned its reputation as the go-to kickstart for long-ester cycles. You front-load 50 mg/day for 4-6 weeks while your longer-acting injectables (Testosterone, Deca) build up to saturation. By the time the orals are discontinued, the injectables have taken over, providing a seamless transition.

Synergistic Stacking Examples:

• The "Classic Mass Kickstart":Oxymetholone 50 mg/day (weeks 1-4) + Testosterone Enanthate 500 mg/week + Deca-Durabolin 400 mg/week. The most powerful bulking stack available.
• The "Strength Peaking" Stack:Oxymetholone 50 mg/day + Testosterone Propionate 100 mg EOD + Trenbolone Acetate 50 mg EOD. Designed for powerlifters seeking maximum strength.
• Crucial Note:Testosterone base is mandatory never run oxymetholone standalone. Keep Nolvadex (10-20 mg/day) on hand for gynecomastia management, as AIs are ineffective. TUDCA 500-1000 mg/day is strongly recommended for liver support.

Post-Cycle Therapy (PCT)

Zyvex Pharma Oxymetholone causes significant HPTA suppression despite being an oral steroid. At standard bodybuilding doses of 50-100 mg daily, it suppresses LH and FSH significantly with suppression depth comparable to moderate-dose testosterone. Post-cycle bloodwork typically shows total testosterone in the 150-300 ng/dL range, with LH and FSH often suppressed to undetectable levels at higher doses.

The Clearance Advantage:
Oxymetholone has a half-life of approximately 8-9 hours and clears completely within a day of the last dose. This rapid clearance means the crash arrives fast you'll feel the suppression within days, not weeks. It also means you can start PCT immediately there is no waiting period like with injectable esters.

Common  PCT Protocol:

• Nolvadex (Tamoxifen):40/40/20/20 mg/day (Week 1: 40 mg, Week 2: 40 mg, Week 3: 20 mg, Week 4: 20 mg)
• Clomid:50/50/25/25 mg/day (Week 1: 50 mg, Week 2: 50 mg, Week 3: 25 mg, Week 4: 25 mg)
• Alternative:Enclomiphene 25 mg/day × 4-6 weeks
• Crucial Addition:Continue TUDCA 500-1000 mg/day through the PCT window to support continued liver recovery
• Lipid Support:Omega-3 fatty acids (6 g/day) and Citrus Bergamot to support HDL recovery

Crucial Note: Oxymetholone demands a PCT that addresses hormones, liver, and lipids simultaneously. Miss any of these three, and you've only partially recovered.

Potential Side Effects

Zyvex Pharma Oxymetholone carries the most severe side-effect profile of any oral steroid. The risks are dose-dependent and cumulative every additional week of use compounds the danger.

Hepatic (Liver) Toxicity:

As a 17-alpha-alkylated compound, oxymetholone is significantly hepatotoxic. Long-term use can cause liver tumors or blood-filled cysts (peliosis hepatitis) in the liver or spleen. These cysts are sometimes present with minimal hepatic dysfunction but can be associated with liver failure and fatal intra-abdominal hemorrhage. Liver cell tumors have been reported most are benign and androgen-dependent, but fatal malignant tumors have occurred. Cholestatic hepatitis and jaundice occur at relatively low doses. Clinical jaundice may be painless, with or without pruritus.

Cardiovascular and Lipid Effects:

Oxymetholone causes marked blood lipid changes: decreased HDL (good cholesterol) and increased LDL. These changes can have a serious impact on the risk of atherosclerosis and coronary artery disease. HDL cholesterol decreases by 19-23 mg/dL at standard doses. Edema with or without congestive heart failure has been reported.

Estrogenic Side Effects:

Despite not aromatizing, oxymetholone produces notable estrogenic effects: water retention, gynecomastia (breast swelling or tenderness in men or women), and mood changes. Aromatase inhibitors are ineffective for managing Anadrol-related gyno. Only SERMs like Nolvadex provide protection.

Androgenic Side Effects:

Acne, male pattern baldness, increased body and facial hair. Virilization in women voice deepening, enlarged clitoris, menstrual changes can be irreversible if treatment is continued.

Suppression and Sexual Effects:

Significant HPTA suppression. Loss of interest in sex, impotence, trouble having an orgasm, decreased semen volume. Paradoxically, increased interest in sex and painful/ongoing erections have also been reported.

Gastrointestinal and Other Effects:

Nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools. Rapid weight gain (especially in face and midsection). Easy bruising or bleeding. Sleep problems (insomnia).

Contraindications:

Oxymetholone is contraindicated in: carcinoma of the prostate or breast in males; carcinoma of the breast in females with hypercalcemia; pregnancy; nephrosis or nephrotic phase of nephritis; hypersensitivity; and severe hepatic dysfunction.

Red Flag Warnings:

Discontinue immediately and seek medical attention if you experience: nausea with upper stomach pain; rapid weight gain (especially face and midsection); dark urine or clay-colored stools; jaundice (yellowing of skin/eyes); painful or difficult urination; easy bruising or bleeding; shortness of breath (even with mild exertion); or swelling in hands or feet.

• Mandatory Protocol: Bloodwork is non-negotiable. Monitor liver enzymes (AST/ALT), lipid panel (HDL/LDL), complete blood count (hematocrit), and estradiol at weeks 2 and 4 of your cycle. Liver enzymes at 50 mg/day frequently rise significantly at 100 mg/day, ALT can rise 72 U/L.

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